
Thyrotropin-Releasing Hormone (TRH) Free Acid
CAS No. 24769-58-2
Thyrotropin-Releasing Hormone (TRH) Free Acid( TRH-OH )
Catalog No. M20830 CAS No. 24769-58-2
Thyrotropin-Releasing Hormone (TRH) Free Acid (TRH-OH) causes a variety of thyroidal and non-thyroidal effects the best known being the feedback regulation of thyroid hormone levels.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 41 | In Stock |
![]() ![]() |
10MG | 67 | In Stock |
![]() ![]() |
25MG | 104 | In Stock |
![]() ![]() |
50MG | 140 | In Stock |
![]() ![]() |
100MG | 214 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameThyrotropin-Releasing Hormone (TRH) Free Acid
-
NoteResearch use only, not for human use.
-
Brief DescriptionThyrotropin-Releasing Hormone (TRH) Free Acid (TRH-OH) causes a variety of thyroidal and non-thyroidal effects the best known being the feedback regulation of thyroid hormone levels.
-
DescriptionThyrotropin-Releasing Hormone (TRH) Free Acid (TRH-OH) causes a variety of thyroidal and non-thyroidal effects the best known being the feedback regulation of thyroid hormone levels.
-
In VitroTRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [3H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na+ channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na+ current amplitude is reduced by 20-50%.
-
In Vivo——
-
SynonymsTRH-OH
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number24769-58-2
-
Formula Weight363.37
-
Molecular FormulaC16H21N5O5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?H2O : 100 mg/mL (275.20 mM)
-
SMILESO=C1CCC(C(=O)NC(Cc2c[nH]cn2)C(=O)N2CCCC2C(=O)O)N1
-
Chemical Name((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-proline
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Kagabu Y Mishiba T Okino T et al. Effects of Thyrotropin-Releasing Hormone and Its Metabolites Cyclo(His-Pro) and TRH-OH on Growth Hormone and Prolactin Synthesis in Primary Cultured Pituitary Cells of the Common CarpCyprinus carpio[J]. General & Comparative Endocrinology 1998 111(3):395-403.
molnova catalog



related products
-
6-Aminofluorescein
6-Aminofluorescein (6-AF) is a new fluorescence marker.
-
Vanicoside B
Vanicoside B is a natural product for research related to life sciences.
-
Bernardioside A
Bernardioside A is a natural product.